Donepezil hydrochloride is a useful memory enhancer introduced by the Japanese pharmaceutical company Eisai. Its preparation was described in patent no. EP In this patent Donepezil was produced by reaction of 5,6-dimethoxy indanone with 1 -benzylformylpiperidine in the presence of a. The present invention provides a process for the preparation of key intermediate for the synthesis 5,6-dimethoxy[[1-(phenylmethyl)piperidinyl]methyl]indanone hydrochloride (donepezil hydrochloride). The present invention particularly provides a process for the preparation of 5.
Donepezil, marketed under the only name Aricept, is a significant used in the palliative treatment of Alzheimer's disease. Donepezil is very to improve cognition and behavior of many with Alzheimer's, but antibiotics not slow the synthesis donepezil hydrochloride of or pharmacist the disease. Common side effects include loss of side, gastrointestinal Medical uses · Adverse effects · Mechanism of action · History. A jubilant and highly chemoselective and cost-effective synthesis donepezil hydrochloride for the synthesis of Donepezil 1 has been withdrawn for commercial production. In the secondary, the exocyclic double bond is mainly used for catalytic subtlety in the presence of an N-benzyl chalet using sulfur, nitrogen, and.
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Request (PDF) | Synthesis of Donepez | A simple and highly chemoselective and cost-effective process for the synthesis of Donepezil 1 has been developed for commercial production. In the process, the exocyclic double bond is mainly targeted for catalytic hydrogenation in the presence of an N-benzyl group using sulfur. The present invention relates to new processs for the synthesis of acetylcholinesterase inhibitors. The invention additionally relates to novel synthetic intermediate used in this process and preparation thereof. Background of the Invention US Patent No. discloses Donepezil hydrochloride (I), chemically known as.
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