In a rat model of lithium-induced nephrogenic DI, the authors describe that HCTZ treatment is able to modulate the expression of renal proteins important for water and sodium reabsorption in the collecting system (18). The employed experimental model is of major clinical importance since nephrogenic DI. Nephrogenic diabetes insipidus (NDI) is characterised by the inability of the kidney to concentrate urine in response to arginine vasopressin. The consequences are severe polyuria and polydipsia, often associated with hypertonic dehydration. Intracerebral calcification, seizures, psychosomatic retardation, hydronephrosis.
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I don't undersand the mechanism of how Hydrochlorothiazide is used to treat nephrogenic diabetes insipidus. I understand that it works at the early. Nephrogenic diabetes insipidus (nephrogenic DI) results from partial or complete resistance of the kidney to the effects of antidiuretic hormone (ADH). As a result, patients Amiloride-hydrochlorothiazide versus indomethacin-hydrochlorothiazide in the treatment of nephrogenic diabetes insipidus. J Pediatr.
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